Transvestia

that anatomical maleness and neural maleness are distinct phenomena, one anatomical-phsiological and the other behavioral and that they do not develop at the same time. Next it should be evident that when an event depends on a crucial deadline there is the inherent possibility of variation of a little too soon or a little too late. Moreover when the event depends upon the presence of a specific compound at a specific location there is by implication, the problem of concentration with the inherent possibility of too little, just right or too much.

Now Sheila in her paragraphs 8 and 11 touched on this situation albeit not completely enough, nor in my opinion, accurately enough and drew some un- warrented conclusions. Commenting now on these para- graphs: The mammalian organism as I have indicated and as Sheila says in regard to the brain only, is essentially a female. Somewhere in evolution a mutation evidently took place in which the substances known collectively as estrogens (there are several forms of estrogen) were slightly modified chemically to produce other materials collectively known as androgens such as androsterone and testosterone. These chemicals differ from the estrogen originals in only minor chemical ways, but these differences are such that they brought about the beginnings of the two-sex type of reproduction. Today in higher animals they continue to act as switches which shift the developmental pattern of an organism to another track, that of maleness. To do so they must be pre- sent at the right time and at the right place in the right quantity. Where I think Sheila is wrong in paragraph 11 is, "the TV gets only enough male hormone to masculinize part of his brain, leaving female areas". This is, from what I can gather in a personal conversation with Dr. Gorski of UCLA who is one of the principle workers in this area, a very unwarrented assumption. To begin with there is no indication that the whole brain is "masculinized" but only certain areas which will be concerned with

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